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January 12, 2018

Question of the Day – Friday January 12, 2018

Question: Does the maternal prenatal use of fluconazole increase the risk of congenital malformations in offspring?

Answer: A recent systematic review “aimed to examine the risk of congenital malformations in the offspring of women exposed to fluconazole in the first trimester of pregnancy.” These authors reported “The rate for overall malformations was 1.10 (95% CI 0.98–1.25), for heart defect was 1.29 (95% CI 1.05–1.58), for craniofacial defects was 1.25 (95% CI 0.88–1.77), and for limb/musculoskeletal defects was 0.82 (95% CI 0.59–1.13).” The authors concluded “……the use of fluconazole in the first trimester does not appear to increase the overall risk for congenital malformations. More studies are needed to address the potential increased rate of heart defects.” (Alsaad AMS et al. Exposure to fluconazole and risk of congenital malformations in the offspring: A systematic review and meta-analysis. 2015 Reproductive Tox 52:78-82)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
        • ABAT Examination Study Guide
      • Certification Renewal Documents
      • Life Long Learning Articles (LLSA)
      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Addiction Toxicology Section
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
      • Geriatric Toxicology
      • Occupational / Environmental
      • Envenomations
      • Forensic
      • Pediatric
      • Weapons of Mass Destruction
      • Toxicology History
      • Radiation
      • Trainee and Student
    • Student Chapters
  • NACCT Annual Meeting
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    • Abstract Submissions
    • After the Fact CE
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