Question of the Day – Wednesday January 16, 2019

Question – What is the mechanism for the development of tick paralysis?

Answer- The cited article notes “Tick paralysis is caused by salivary neurotoxins that are secreted by gravid female ticks while blood feeding. Although the exact mechanism by which these toxins produce paralysis is not known, animal experiments have demonstrated that the presynaptic release of acetylcholine is somehow affected.” (Pecina CA. Tick paralysis. 2012 Semin Neurol 32:531-532)