Question of the Day – Tuesday February 5, 2019

Question – Andexanet alfa is a class specific antidote approved for the reversal of Factor Xa inhibitors (e.g. apixaban, rivaroxaban). What are the factors that influence the recommended dosing of andexanet alfa?

Answer- The cited monograph notes “The recommended dosing of Andexanet alfa is based on the specific Factor Xa inhibitor, the dose of Factor Xa inhibitor and time since the patient’s last dose of Factor Xa inhibitor.” (Gibler WG [Editor] Proceedings Monograph from the EMCREG- International Multidisciplinary Sever Bleeding Consensus Panel, October 20, 2018, University of Cincinnati.)