Question of the Day – Monday February 11, 2019

Question -The so-called “red man syndrome” (RMS) is a recognized adverse reaction that may occur in patients receiving vancomycin. What are the risk factors for the development of red man syndrome specifically in pediatric patients?

Answer- The cited article reports “Identified risk factors are Caucasian ethnicity, age >/=2 years, previous RMS history, vancomycin dose >/=10 mg/kg, vancomycin concentration, >/=5 mg/mL and antecedent antihistamine use. Known genetic variants in histamine metabolism or receptors do not appear to be substantial contributors to risk of RMS. (Myers AL et al. Defining risk factors for red man syndrome in children and adults. 2012 Pediatr Infect Dis J 31:464-468)