Question of the Day – Friday June 16, 2017

Question: What are the unique aspects of norbormide rat poison?

Answer: According to the cited reference, “Norbormide was introduced in 1964 by McNeil Laboratories Inc., as a toxicant selective for the rat species. Norbormide is a unique vasoactive substance endowed with species and tissue specific, endothelium independent, vasoconstrictor activity that is restricted to the peripheral arteries of rats.” (Bova S et al. Norbormide: a calcium entry blocker with selective vasoconstrictor activity in rat peripheral arteries. 2001 Cardiovascular Drug Reviews 19(3): 226-233)