Question of the Day – Wednesday, May 31, 2023
How do antiarrhythmics, quinidine affect serum digoxin concentrations? Antiarrhythmics can increase serum digoxin concentrations. For example, quinidine decreases tissue binding of digoxin, leading to smaller volume of distribution and higher serum digoxin concentrations. Quinidine may also interfere with digoxin secretion by inhibiting P-glycoprotein in the…