Question of the Day – Thursday, October 27, 2022

According to a recent prospective study, how effective is a single, large dose of intramuscular naloxone in reversing opioid toxicity in adult patients in the outpatient setting? In the cited reference, a single 1.6 mg IM dose of naloxone was effective in initially reversing respiratory…

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Question of the Day – Wednesday, October 26, 2022

In the out-of-hospital setting, larger intramuscular doses of naloxone may be used because the IM route is more rapid and reliable. What is the frequency of severe agitation following administration of a single 1.6 mg IM naloxone dose in patients with opioid toxicity in the…

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Question of the Day – Monday, October 24, 2022

In the out-of-hospital setting, larger intramuscular doses of naloxone may be used because the IM route is more rapid and reliable. What is the frequency of severe agitation following administration of a single 1.6 mg IM naloxone dose in patients with opioid toxicity in the…

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Question of the Day – Wednesday, September 28, 2022

What is Samidorphan? Samidorphan is a µ-opioid receptor antagonist that also has partial agonist activity at κ- and δ-opioid receptors in vitro. It has µ-opioid antagonist effects that last up to 24 hours and hasgreater affinity for the µ-opioid receptor than both naltrexone and buprenorphine. In…

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