Question of the Day – Wednesday, May 31, 2023
How do antiarrhythmics, quinidine affect serum digoxin concentrations? Antiarrhythmics can increase serum digoxin concentrations. For example, quinidine decreases tissue binding of digoxin, leading to smaller volume of distribution and higher serum digoxin concentrations. Quinidine may also interfere with digoxin secretion by inhibiting P-glycoprotein in the…
Question of the Day – Tuesday, May 30, 2023
How do macrolides and tetracyclines affect serum digoxin concentrations? Macrolide antibiotics such as clarithromycin and erythromycin, and tetracyclines such as tetracycline and doxycycine alter the normal flora of the gut, including Eubacterium lentum. Under normal conditions, Eubacterium lentum inactivates digoxin in 10 – 15% of…