Question of the Day – Monday, May 29, 2023
High dose insulin (HDI) improves shock via at least four mechanisms. What are they? 1. HDI acts as a potent inotrope, increasing stroke volume and therefore cardiac output by calcium-dependent and calcium-independent pathways in myocardial cells. 2. HDI optimizes myocardial energy utilization as stressed myocardial…
Question of the Day – Friday, May 26, 2023
A recent retrospective study of calcium channel blocker poisoned patients found that patients with amlodipine poisoning experienced more vasodilation when treated with high-dose insulin (HDI) than those poisoned by of non-dihydropyridines. What is the proposed mechanism? HDI acts as a vasodilator via enhancement of endothelial…