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March 23, 2018

Question of the Day – Friday March 23, 2018

Question- Vincristine (VCR) is commonly used in the treatment of acute lymphoblastic leukemia (ALL). What are the common adverse effects and toxicities associated with the use of vincristine?

Answer- The cited reference notes: “The most common side effects of VCR are gastrointestinal toxicity, peripheral neuropathy, electrolyte abnormalities, and autonomic neuropathy. Abdominal pain, constipation, and ileus are the most common gastrointestinal side effects. Difficulty walking or standing, muscular weakness, loss of deep tendon reflexes, and neuropathic pain are signs of VCR-related peripheral neuropathy. Hypertension is the most common manifestation of autonomic neuropathy. (Pekpak E et al. Toxicity of vincristine combined with posaconazole in children with acute lymphoblastic leukemia. 2017 J Pediatr Hematol Oncol, early online)

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  • Education & Groups
    • American Board of Applied Toxicology (ABAT)
      • ABAT Exceptional Service Award
      • ABAT Newsletter
      • Sitting for the American Board of Applied Toxicology Exam
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      • ABAT Member Directory
        • Diplomate Verification
      • ABAT Board of Directors Contact Information
    • E-Learning
      • Advanced Hazmat Life Support Training
      • MMTI Fundamentals for Front-Line Practitioners Training
      • TOXISMO Society for the Discussion of Scientific Literature
      • ToxNow
      • Webinars
        • ABAT Journal Club Webinars
        • COVID Webinar Series
    • Toxicology Residency & Fellowship Training Programs
    • Clinical Toxicology Guidelines Collaborative
      • Recommendations
    • Fellows of AACT
    • ToxCoach Mentorship Program
    • Committees
    • Sections
      • Acute & Intensive Care
      • Clinical Toxicology In Sports
      • Diversity, Equity, and Inclusion Section
      • Herbs & Dietary Supplements
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      • Occupational / Environmental
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