Question of the Day – Wednesday November 24, 2021
In a meta-analysis examining the risk of adverse events associated with the use of flumazenil in patients with impaired consciousness due to a known or suspected benzodiazepine overdose, what was the most common adverse event? Aggressiveness defined as agitation, screaming or restlessness Penninga EI, Graudal…
Message from AACT’s President, Dr. Kirk Cumpston
November 23, 2021 November is a month to reflect and give thanks for the bounty in our lives and the sacrifices of our active duty and veterans in the Armed Services. When times are uncertain, you can find strength in the knowledge that your community…
Question of the Day – Tuesday November 23, 2021
According to a recent study, what characteristics are associated with diphenhydramine toxicity that result is more severe outcomes? Acidemia, prolonged QRS and elevated anion gap. Hughes AR, Lin A, Hendrickson RG; Toxicology Investigator’s Consortium (ToxIC). Clinical and patient characteristics associated with severe outcome in diphenhydramine…
Question of the Day – Monday November 22, 2021
Abacavir hypersensitivity is life threatening and occurs in 5-8% of patients. What gene is implicated? HLA-B*57:01. It is believed that short peptide fragments of abacavir form a peptide HLA-complex with HLA-B*57:01 which activates CD8+ T cells which then induce a hypersenstivity response. The CPIC &…
Question of the Day – Friday November 19, 2021
What is the clinical significance of the drug interaction between valproate and carbapenem antibiotics? Carbapenem antibiotics decrease serum valproate concentrations within 1-3 days after treatment initiation of the carbapenem. In a recent meta analysis, the mean reduction of valproate concentrations was 43.98 mg/L. Seizure frequency…
AACT Members in the Military
AACT recognizes Veterans’ Day and celebrates its members. “My time in the US Navy Reserve was atypical, short, and impactful. Having always wanted to serve and being deeply impacted by 9/11, my number was eventually called. After several discussions with veterans (including Drs. Wills and…
AACT Members in the Military
AACT recognizes Veterans’ Day and celebrates its members. “When reflecting on my time on active duty, my most profound experience was deploying with the 47th Combat Support Hospital (CSH) to Mosul and Tikrit, Iraq. In 2006 there was intense fighting resulting in multiple daily trauma…
Question of the Day – Thursday November 18, 2021
What was the relative decrease of Torsades de Pointes with a single dose of activated charcoal given within 1 hour of greater than 600 mg of citalopram overdose? In this in-vivo study, modeling predicted that charcoal given within 60 minutes resulted in a relative decrease…
Question of the Day – Wednesday November 17, 2021
What clinical effects are more common in Type 2 pyrethroid poisoning cases rather than type 1 pyrethroid cases? In a recent study of 59 patients (16 had been exposed to type 1 pyrethroids and 43 had been exposed to type 2 pyrethroids) by Jacob et…
The History of Modern Clinical Toxicology Book Available
History of Modern Clinical Toxicology describes the extraordinary advances in the practice of clinical toxicology within the past 70 years and brings together stories of the people – the champions of clinical toxicology – who contributed to these advances, discovered new therapies and antidotes, and…