Administrator Clintox - One

A recent case series described three patients with loperamide use disorder who were successfully treated with what medication? Long-term buprenorphine. According to the authors, buprenorphine can be used for loperamide use disorder, most effectively when patients are in mild to moderate withdrawal. Brar, Jessica K….

In a recent review article, what strategy was found to improve treatment retention among patients receiving medications for opioid use disorder (MOUD)? Though most studies did not focus on retention as the primary outcome, consistent but sparse evidence supported initiating MOUD in soon-to-be-released incarcerated people…

What strategies can be employed to manage side effects of buprenorphine/naloxone? According to the cited reference, there are several strategies to manage side effects of buprenorphine/naloxone: (1) gradual dose reduction while monitoring for withdrawal, (2) split dosing to minimize side effects related to rapid increases…

What are the most common side effects of buprenorphine/naloxone treatment? According to the package insert for the Suboxone film, the most common side effects are headache (36%), nausea (15%), and vomiting (8%). Other potential side effects include constipation, pain, increased sweating, and insomnia. https://www.suboxone.com/content/pdfs/prescribing-information.pdf  

It has been noted that the residual calculated osmolal gap increases with increasing ethanol levels. Purssell et al. found that there is a linear relationship between the serum ethanol level and the osmolal gap. What do they suggest the multiplicative factor for ethanol in formulas…

Patients with this genetic polymorphism are potentially at higher risk of the decreased therapeutic effect of diazepam? Skryabin VY et al. recently evaluated the effects of CYP2C19 genetic polymorphisms on the steady state concentration of diazepam in patients with alcohol withdrawal syndrome. They postulate that…

This has been an effective and well-tolerated treatment strategy for patients with major depressive disorder who are partial or non-responders to antidepressant therapy? L-methylfolate 15 mg/day added to SSRIs or as monotherapy can be an effective and well tolerated treatment strategy. It is particularly effective…

What is the case fatality rate for dinitrophenol? Gziut T et al. retrospectively evaluated dinitrophenol exposures from 38 countries between January 2010 and September 2020. 456 separate cases of DNP exposures were evaluated. Case fatality overall was 11.9% (95% CI 9, 15.4). Gziut T &…

What is the most common home remedy used in Nigeria for pediatric poisonings? A retrospective study of 127 children that presented to the emergency department in a teaching hospital in Nigeria from 1989 through 1998 revealed that oral administration of palm oil is the most…