What was the relative decrease of Torsades de Pointes with a single dose of activated charcoal given within 1 hour of greater than 600 mg of citalopram overdose?
In this in-vivo study, modeling predicted that charcoal given within 60 minutes resulted in a relative decrease of tdP of 60%. The activated charcoal workgroup summarized the available evidence on the efficacy of activated charcoal.
Hoegberg LCG et al. Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose. Clin Tox 2021. https://doi.org/10.1080/15563650.2021.1961144