Question Of The Day

In a review of the English literature of fatalities from serotonin syndrome from 1981-2020, most fatalities had an onset of serotonin syndrome ≤ or > 24 h? Roughly 60% had symptoms ≤ 24 hours and 50% died ≤ 24 hours. Sanjay Prakash, Chaturbhuj Rathore, Kaushik…

In a review of the English literature of fatalities from serotonin syndrome from 1981-2020, the most common symptom was? Fever. The mean temperature was 41.6°C (range 38.3-43.5) Sanjay Prakash, Chaturbhuj Rathore, Kaushik Rana & Anurag Prakash (2021) Fatal serotonin syndrome: a systematic review of 56…

The above compound is the primary psychoactive ingredient from which spice?   Myristicin is a serotonergic compound in nutmeg https://pubchem.ncbi.nlm.nih.gov/compound/4276

Despite its touted benefits, what high risk behavior may lead to suppressed host-defense functions in the context of respiratory viral infections? Electronic cigarettes A recent study comparing nonsmokers, cigarette smokers and e-cigarette smokers concluded e-cigarette use altered nasal live-attenuated influenza virus (LAIV)-induced immune responses, including…

Co-ingestion of what xenobiotic is associated with an increased risk of MALA when compared with metformin ingestion alone?   Acetaminophen co-ingestion In a retrospective observational cohort study of ED patients presenting with acute drug overdose, acetaminophen co-exposure was associated with over a 24-fold increased risk…

Using methamphetamines with opioids has been nicknamed “Goofball.” In a study of patients with opioid used disorder presenting to the Emergency Department, greater than 50% of the cohort with a urine screening positive for an amphetamine-type substance were white men who never married; were unemployed;…

This drug combination was recently studied for methamphetamine use disorder?   Naltrexone and Bupropion. In a recent randomized, placebo controlled study, injectable naltrexone 380 mg every 3 weeks) plus oral bupropion XL 450 mg daily was given to patients with methamphetamine use disorder. Trivedi MH…

Which compound, found in many plastics, adhesives, glues, laminated products such as plywood, cement, cleansers, fire-retardant paint was added to infant formula to increase the apparent protein content in infant formula in China in the late 90’s and early 2000’s? What toxicity is associated with…

In 1997, 39 men and women belonging to Heaven’s Gate died during a mass suicide in Rancho Santa Fe California. What was the reported method of suicide? A combination of phenobarbital, alcohol, and asphyxiation. https://en.wikipedia.org/wiki/Heaven%27s_Gate_(religious_group)

What complication is associated with intravenous injection of the sedative hypnotic drug associated with a “smell of shower curtain”?   Ethchlorovynl injection has been reported with temporal relationship to development of pulomnary edema. Miller KS, Sahn SA. Bilateral exudative pleural effusions following intravenous ethchlorvynol administration….