Question of the Day – Monday June 15, 2020
In a recent population based cohort study from Canada, there was a 75% increase in ED visits and near doubling of hospitalizations from 2010-2015 due to intentional overdose in youth. What were the most common substances involved in the overdoses? The most common substances…
Question of the Day – Friday June 12, 2020
Suicide is the second leading cause of death among adolescents. What is the risk of a nonfatal suicide attempt within one year? A nonfatal suicide attempt is a strong risk factor for completed suicide. There is a 32 fold increase in the risk of…
Question of the Day – Thursday June 11, 2020
What is the dermatological abnormality associated with chronic abuse of nitrous oxide? According to the cited reference, “The distribution and shade of pigmentation varied from patient to patient, but the most typical distribution is on the hands and feet, especially in the interphalangeal joint…
Question of the Day – Wednesday June 10, 2020
Genetic polymorphisms of which hepatic enzyme may influence the observed variable toxification of acrylonitrile? According to the cited reference, acute toxicity of acrylonitrile is dependent on its toxification to cyanide by CYP2E1. Significant variation in metabolic formation of cyanide has been observed in humans…
Question of the Day – Tuesday June 9, 2020
At a dose of 4 mg oral cyproheptadine TID, what percentage of CNS 5-HT receptors are blocked? According to the cited reference, at 4 mg TID, cyproheptadine blocks 85% of 5-HT receptors. At a dose of 6 mg TID, an estimated 95% of receptors…
Question of the Day – Monday June 8, 2020
A recent review outline the adverse events associated with single agent diphenhydramine exposure in children under 12 years of age. What was the frequency of associated seizures? The cited reference reports seizure in 5.5% of 2023 non fatal single ingredient exposures 2008-2015. (Palmer Rp…
Question of the Day – Friday June 5, 2020
This rodenticide, when mixed with water, produces a highly toxic gas that inhibits oxidative respiration. Zinc phosphide is classified as a highly toxic rodenticide because it has an LD50 of less than 50 mg/kg. It impairs oxidative respiration by inhibition of oxidative phosphorylation. It…
Question of the Day – Thursday June 4, 2020
Venom of Heloderma suspectum, known as the Gila monster, has been of interest for drug development. Exendin-4 was identified and found to bind glucagon-like peptide-1 receptor and is used in the treatment of diabetes. GLP-1 receptors are also found in the brain and because of…
Question of the Day – Wednesday June 3, 2020
In a recent cohort study, carbon monoxide poisoning appeared to be associated with an increased risk of this complication in the first 90 days after poisoning? Cho et al. performed a cohort study in carbon monoxide poisoned patients and found an increased risk of…
Question of the Day – Tuesday June 2, 2020
Seizures and sympathomimetic effects are well-described after bupropion toxicity. This effect, however, is more controversial. In a recent retrospective analysis of single agent bupropion exposures, 13 patients (5.9%) were diagnosed with serotonin toxicity. (Murray B et al. Single Agent Bupropion exposures: Clinical characteristics and…