Retinal pigment epithelium (RPE) changes have recently been described in a small subset of patients with poisoning from what?
Organophosphates. In a recent study of 16 patients with organophosphate poisoning, RPE changes were the most commonly observed changes. The RPE is known to have α7 nicotinic ACh receptors located on the outer microvilli and this is one potential hypothesized mechanism.
Dahanayake P et al. Dysfunction in macula, retinal pigment epithelium and post retinal pathway in acute organophosphorus poisoning. Clin Tox 2021; 59(2): 1111-1117. https://doi.org/10.1080/15563650.2020.1771359