Question of the Day – Monday, February 14, 2022
What is Lorcaserin, and why was it removed from the market in 2020? Lorcaserin is a serotonin 2C receptor agonist that modulates appetite, and was prescribed for weight loss. It was removed from the market because of concerns of increased risk of lung and pancreatic…
Question of the Day – Friday, February 11, 2022
What weight loss agent was withdrawn from the market in 2010 for a 16% increase in myocardial infarction, non-fatal stroke, resuscitation after cardiac arrest, and cardiovascular death? Sibutramine James WP, Caterson ID, Coutinho W, Finer N, Van Gaal LF, Maggioni AP, Torp-Pedersen C, Sharma AM,…
Question of the Day – Thursday, February 10, 2022
Which antiplatelet agent was discontinued as of 2015 for concerns of agranulocytosis, thrombotic thrombocytopenic purpura and aplastic anemia? Ticlopidine LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Ticlopidine. [Updated 2020 Sep…
Question of the Day – Wednesday, February 9, 2022
Terfenadine was pulled from the market for which life threatening adverse effect? In 1997, Terfenadine was removed from the market for concerns of TdP secondary to Ikr blockade, particularly in the context concomittent treatment with drugs blocking its metabolism (CYP 3A4 inhibition). The use was…
Question of the Day – Tuesday, February 8
In a recent comparison of hospital claims and poison center data there was a discordance specifically due to what class of drugs? Wang GS et al. compared hospital claims from the Colorado Hospital Association and poison center cases from the Rocky Mountain Poison and Drug…
Question of the Day – Friday, February 4
These echocardiogram findings were associated with higher mortality in patients with aluminum phosphide poisoning? Left-ventricular ejection fraction (LVEF) and left ventricular hypokinesia. Elgazzar FM et al. examined 90 patients from September 2019 through December 2020 with acute aluminum phosphide poisoning. Survivors had a higher mean…
Question of the Day – Thursday, February 3, 2022
What were the common characteristics in pediatric deaths associated with exposures to cough and cold medications from 2008 through 2016? Children < 2 years with 65% in boys and deliberate administration of a cough and cold medication by a caregiver largely for a nontherapeutic intent….
Question of the Day – Wednesday, February 2, 2022
Calcium carbide is used industrially as a welding agent due to the liberation of flammable acetylene gas on contact with moisture. It is included in the Toxic Substances Control Act (TSCA) Chemical Substance Inventory of the Environmental Protection Agency (EPA). Industrial acetylene gas behaves as…
Question of the Day – Tuesday February 1, 2022
When evaluating a patient with potential myocarditis secondary to an Immune Checkpoint Inhibitor, what criteria should be used to aid in the diagnosis and treatment? Bonaca’s criteria. Bonaca MP et al. Myocarditis in the Setting of Cancer Therapeutics. Circulation 2019; 140(2):80-91. https://doi.org/10.1161/CIRCULATIONAHA.118.034497
Question of the Day – Monday January 31, 2022
In a patient with acetaminophen-induced hepatotoxicity, what may the thromboelastography (TEG) show? In a recent retrospective review of nine patients who were admitted for acetaminophen toxicity to a transplant center, TEG showed a decreased rate of fibrin formation and cross linking as well as decreased…