Administrator Clintox - One

The use of valproic acid in critically ill patients can result in toxic encephalopathy due to elevated plasma concentrations of what compound? The use of valproic acid (e.g., Depakote) in critically ill patients frequently results in elevated plasma concentrations of ammonia. The hyperammonemic encephalopathy associated…

Why are newborns more susceptible to the development of methemoglobin? Newborns have a lower activity of cytochrome b5 reductase, estimated to be 50-60% of adult values. Raucci U et al. Acquired methemoglobinemia in children presenting to Italian pediatric emergency departments: A multicenter report. Clin Tox….

This novel topical treatment has shown promise for the treatment of brown recluse spider bites. Topical Diethyl Axelate (DEA). Streeper RT et al. Diethyl Azelate for the Treatment of Brown Recluse Spider Bite, a Neglected Orphan Condition. in vivo 2022; 36:86-93. doi:10.21873/invivo.12679

This antidepressant, recently reported to have benefits in the treatment of COVID-19, is a potent CYP 1 A 2 inhibitor. Fluvoxamine. Cole JB et al. recently reported a case of theophylline toxicity after the initiation of fluvoxamine intended to treat COVID-19. Cole JB et al….

What is the mechanism of action of taxine B? The mechanism of its effect involves the elevation of cytoplasmic calcium in cardiac myocytes with sodium and calcium channel antagonism. According to the cited reference, the effect is similar to that of verapamil. Ondřej Piskač, Jan…

The Common Yew (Taxus baccata) contains at least 10 different alkaloids that are contained in yew berries, needles, or bark. Of these, which alkaloid is the most active cardiotoxin? Taxine B. The major taxine alkaloids are taxine A and taxine B, and taxine B is…

What antidote for a critically poisoned patient can interfere with point-of-care (POC) glucose measurements? Hydroxocobalamin. In a patient treated with hydroxocobalamin after rescue from a house fire, POC glucose measurements averaged 61 mg/dL (3.4 mmol/L) lower than glucose measured in a basic metabolic panel (BMP)….

In a recent prospective study of 59 patients that ingested pyrethroids, what exam signs were seen exclusively in type 2 pyrethroid ingestions compared to type 1 pyrethroid ingestions? The study included 43 patients with type 2 pyrethroid ingestions and 16 patients with type 1 pyrethroid…

In a recent study of the safety and quality of various dietary supplements, how often did the products have accurate labeling? Crawford C et al. evaluated and performed product analysis on 41 dietary supplement products. Only 26.8% of the products had accurate labeling. 63.4% were…