Administrator Clintox - One

A medicinal diluent prompted the passage of the Food, Drug, and Cosmetic Act of 1938 after it resulted in an outbreak of mass nephrotoxicity and deaths. What is the toxic metabolite of this diluent that is believed to be responsible for nephrotoxicity? Diglycolic acid (DGA)…

Since 1994, there have been 7 cases of pneumonia with 2 fatalities amongst welders and other metalworkers in Louisiana or Texas. What was determined to be the cause? Fatal Anthrax Pneumonia Caused by Bacillus cereus Group Bacteria Containing Anthrax Toxin Genes. Dawson P, Schrodt CA,…

What is Ioderma? Ioderma is an idiopathic reaction characterized by acneiform, vesicular pustular, hemorrhagic, or urticarial lesions. Other systemic side effects of SSKI include urticaria, fever, eosinophilia, jaundice, pruritus, angioedema, and bronchospasm. High-dose steroid is the therapy of choice, with prompt regression of the symptomatology….

What is the Wolff-Chaikoff effect? In cases of excess iodine, iodine uptake in the thyroid gland is blocked by a decreased activity of the iodine symporter, leading to reduced T4 and increased TSH concentrations. Vlaardingerbroek H. Unusual cause of congenital hypothyroidism in a term infant….

In a recent retrospective study of both acute and chronic lithium poisoned patients, how well did the lithium nomogram predict patients that would have a lithium concentration of < 1 mEq/L at 36 hours? Sam K et al. performed a retrospective analysis of both acute…

A reduction in this dietary exposure is associated with a decline in mortality from primary liver cancer? Aflatoxin. Chen JG et al. Reduced Aflatoxin Exposure Presages Decline in Liver Cancer Mortality in an Endemic Region of China. Cancer Prev Res 2013; 6(10): 1038-1045.

In a recent case report, what was the elimination half life of thiocyanate? Watson C et al. describe a patient with thiocyanate toxicity. In this patient, thiocyanate demonstrated first order kinetics with an elimination half life of 61.6 hours. Watson C et al. Thiocyanate toxicity:…

What is the most commonly reported laboratory interference in thiocyanate toxicity? Pseudohyperchloremia. Watson C et al. Thiocyanate toxicity: A Teaching Case. Clin Tox 2022. Published online 4 March 2022.https://doi.org/10.1080/15563650.2022.20420122

In the early 1900s, a magician added thiocyanate to iron-laced water to “turn water into wine”. What was the premise behind this? In a recent teaching case of thiocyanate toxicity published by Watson C et al., the authors describe the historical use of thiocyanate. Iron…

What is the impact of length of hospitalization after consultation with a single poison center? In a recent retrospective cohort study, Farkas A et al. demonstrated a 16% shorter length of stay. This reduction was equates to a mean reduction of 11.6 hours (10.2 –…