June Message from AACT President, Dr. Kirk Cumpston
June 27, 2022 June has been a blur because of all the events this month, personally and professionally. Which means one third of the summer is almost over too. June is another great transition month, when we wave our hopeful goodbyes to our graduates, who…
Question of the Day – Friday, June 24, 2022
According to a recent study, what is the new synthetic opioid that has been successfully isolated and studied that has a piperidine benzimidazolone structure? Brorphine Verougstraete N, Vandeputte MM, Lyphout C, Cannaert A, Hulpia F, Van Calenbergh S, Verstraete AG, Stove C. First Report on…
Question of the Day – Thursday, June 23, 2022
Based on the findings from the multicenter retrospective study on the impact of marijuana legalization on cannabis-related visits to the emergency department visits in Boston, MA, what are some factors contributing to increased utilization of marijuana in ages > 59 years? Consider to be part…
Question of the Day – Wednesday, June 22, 2022
In a recent case report of a 54 year old male, what was the adverse effect associated with the administration of hydroxocobalamin? Hydroxocobalamin-induced oxalate nephropathy Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep….
Question of the Day – Tuesday, June 21, 2022
In patients with smoke inhalation injury admitted to the ICU what factors were associated with mortality in ICU in this retrospective analysis? Age, severe burns, admission plasma lactate, and SAPS2 Dépret F, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation:…
Question of the Day – Monday, June 20, 2022
In a review of pooled cases of diphenhydramine toxicity refractory to traditional resuscitation methods, which parameters showed improvement after lipid emulsion therapy? In the patients who received LET, the mean arterial pressure (MAP) increased in MAP 37±17.5mm Hg compared to a decrease by 4.5 ±…
Question of the Day – Friday, June 17, 2022
In the RCT looking at High dose ILE, what factor(s) led the authors to question the idea of Intralipids role in “lipid sink compartment” model? 1) RCT exhibited gradual/modest hemodynamic effects from the use of ILE infusion alone. which contrasts case reports,in which, rapid onset…
Soliciting Ideas for the Fellow In Training Webinar
Dear AACT members, We are excited to open up submissions for the AACT Fellow In Training webinar which will be held October 4 2022 at 1pm EDT. This is an opportunity brought to you by the AACT Trainee Section that is open to toxicology fellows…
Question of the Day – Thursday, June 16, 2022
In patients suffering from thiocyanate toxicity, what sort of treatment options are available for the unstable patient? Lipid emulsion therapy may be a suitable therapy option in patients suffering from thiocyanate toxicity as the molecule is lipid soluble. Furthermore, hemodialysis can be considered in patients…
Question of the Day – Wednesday, June 15, 2022
In the randomized controlled study comparing high- dose insulin to vasopressors or combination therapy in a porcine model of refractory propranolol-induced cardiogenic shock, why was it important to maintain a MAP of greater than 55 mmHg? In humans, the literature suggests that cerebral blood flow…