What is the mechanism of action of taxine B?
The mechanism of its effect involves the elevation of cytoplasmic calcium in cardiac myocytes with sodium and calcium channel antagonism. According to the cited reference, the effect is similar to that of verapamil.
Ondřej Piskač, Jan Stříbrný, Hana Rakovcová, et al. Cardiotoxicity of yew. Cor et Vasa. 2015 June 57;3:e234-e238. https://doi.org/10.1016/j.crvasa.2014.11.003
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