Question Of The Day

What medications has been shown in animal and in-vitro models to prevent fluoride induced hyperkalemia? Amiodarone and Quinidine. A study by Su M et al. used an in-vitro model of human blood and showed that both amiodarone and quinidine attenuated fluoride induced hyperkalemia. Su M…

What species of buffalobish is most recently associated with Haff disease? Deeds JR et al. recently investigated cases of Haff disease between 2010 and 2020 in the US. 16 of the 24 samples tested identifed I. bubalus. This is contrary to previous reports that I….

Historical QOD 10/21/08: Describe the pathophysiology involving scorpion envenomation by Centroides exillicauda. C. exillicauda venom consists of primarily neurotoxins causing sodium channel opening at neuromuscular junctions. Repetitive depolarization subsequently occurs in both the sympathetic and parasympathetic nervous system, causing simultaneous acetylcholine and catecholamine surges. (Rimsza…

Which drug is pictured below? Sodium Nitroprusside https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-nitroprusside

What is the management of children with exposures to direct oral anticoagulants (DOACs)? What are the expected outcomes among children? Are specific reversal agents (idarucizumab or andexanet alfa) indicated? A recent systematic review recommends observation and supportive care (which may include oral activated charcoal within…

For a person who injects heroin (diacetylmorphine) and develops toxicity requiring intervention, what is the time interval to need for intervention such as ventilatory support (bag-valve mask) or naloxone? In the Medically Supervised Injecting Room in Melbourne, Australia with 60,693 supervised visits in one year,…

A 2022 review examining lead toxicity from retained bullets found what characteristic of the bullet to influence lead toxicity? If the bullet is jacketed or unjacketed. “Lead absorption from a RB also depends on the type of bullet present. Bullets are commonly composed of an…

Historical QOD 10/09/08: True or False? Sodium azide is responsible for facial and ocular injury due to automobile airbag deployment. False. An alkali aerosol containing sodium hydroxide and sodium carbonate is released into the passenger compartment of the car on airbag deployment. (Can Med J,…

In a recent review of cases of Amanitin intoxication, what laboratory values were found to be possible predictors of potentially fatal outcomes? AST, ALT, Total serum bilirubin, and INR values Tan JL, Stam J, van den Berg AP, van Rheenen PF, Dekkers BGJ, Touw DJ….

Which antidote is pictured below? Prussain blue. https://www.acs.org/content/acs/en/molecule-of-the-week/archive/p/prussian-blue.html