Question Of The Day

In a case report of a zaleplon overdose, what antidote was found to have a possible effect on CNS depression? Flumazenil Jonas Höjer, Heléne Salmonson & Pierre Sundin (2002) Zaleplon-Induced Coma and Bluish Green Urine: Possible Antidotal Effect by Flumazenil, Journal of Toxicology: Clinical Toxicology,…

Historical QOD 10/29/08: Name common medications responsible for phencyclidine false-positive results on urine drug screen immunoassays. Common medications causing phencyclidine false-positives include dextromethorphan, diphenhydramine, ibuprofen, ketamine, meperidine, tramadol, venlafaxine, imipramine, and doxylamine. Moeller KE, et al. Urine drug screening: practical guide for clinicians. Mayo Clin…

In a recent study utilizing NPDS data, what toxic substance was found to induce methemoglobinemia and has had an increasing exposure incidence due accessibility and promotion on social media for use in suicide? Sodium nitrite McCann SD, Tweet MS, Wahl MS. Rising incidence and high…

In a secondary data analysis of a consecutive cohort study, what outcome was sodium bicarbonate therapy associated with? This goal of this study was not to deter sodium bicarbonate use, but to emphasize the importance of close monitoring. Adverse cardiovascular events (ACVE) Shastry S, Ellis…

What therapy was found to be associated with higher survival rates compared with symptomatic care in amanitin mushroom toxicity in a review of 40 cases? Monotherapy with silibinin or benzylpenicillin and combination therapy with N-acetyl cysteine/silibinin Jia Lin Tan, Janine Stam, Aad P. van den…

What risk factors were identified as leading to increased risk of lead toxicity due to retained bullets/fragments in a recent systematic review? Location of the retained fragment, presence of fracture or trauma, number of fragments, hypermetabolic states, and bullet retention duration Emily K. Kershner, Natasha…

Historical QOD 10/28/08: Name the King’s College Criteria for acetaminophen-induced fulminant hepatic failure necessitating liver transplantation, The criteria include a pH < 7.2, PT > 100 seconds, creatinine >3.3 mg/dL, and grade III or IV encephalopathy. Since its inception, the additional criteria of a lactate…

In a study evaluating serotonin syndrome in older adults, what were the most commonly reported symptoms? Tremor and hyperreflexia Erken N, Kaya D, Dost FS, Ates Bulut E, Isik AT. Antidepressant-induced serotonin syndrome in older patients: a cross-sectional study. Psychogeriatrics. 2022 Jul;22(4):502-508. doi: 10.1111/psyg.12849. Epub…

What medication has been applied topically to the site of an esophageal stricture in order to improve the outcome of those requiring endoscopic dilation caused by the ingestion of a caustic agent? Mitomycin C applied topically at the time of dilation has been shown to…

What pathway leads to insulin resistance in calcium channel blocker overdose? Calcium channel blockers cause dysregulation of the phosphoinositide 3-kinase pathway for glucose entry by inhibiting protein kinase B, resulting in insulin resistance and need for high doses of insulin (1-10 units/kg/hr) to treat myocardial…