Historical QOD 10/21/08: Describe the pathophysiology involving scorpion envenomation by Centroides exillicauda.
C. exillicauda venom consists of primarily neurotoxins causing sodium channel opening at neuromuscular junctions. Repetitive depolarization subsequently occurs in both the sympathetic and parasympathetic nervous system, causing simultaneous acetylcholine and catecholamine surges.
(Rimsza ME et al. Scorpion envenomation. Pediatrics 1980;66:298-302)