Question of the Day – Friday, January 20, 2023
In a multicenter retrospective review evaluating seizure risk with escitalopram and citalopram, which agent was associated with increased risk of seizures? Citalopram Yilmaz Z, Ceschi A, Rauber-Lüthy C, Sauer O, Stedtler U, Prasa D, Seidel C, Hackl E, Hoffmann-Walbeck P, Gerber-Zupan G, Bauer K, Kupferschmidt…
Question of the Day – Thursday, January 19, 2023
Historical QOD 11/3/08: Acromelic acids are the probable etiologic agents of what disorder associated with consumption of mushrooms? Erythromelalgia from Clitocybe mushrooms (Toxicological Reviews, 2006, 25(3):199-209)
Question of the Day – Wednesday, January 18, 2023
In a recent case report a large consumption of vanilla essence containing glycerol mimicked which type of toxic exposure? Toxic alcohols Coulson L, Surla A, Tran V, Hoggett K. Severe glycerol intoxication mimicking toxic alcohol ingestion following large volume consumption of vanilla essence. Clin Toxicol…
Question of the Day – Tuesday, January 17, 2023
In a recent retrospective cohort study of venlafaxine overdoses in non-diabetic patients, what amount of patients experienced mild to moderate hypoglycemia? One-third Bekka E, Eyer F. Dose-related hypoglycemia in venlafaxine poisoning: a retrospective cohort study. Clin Toxicol (Phila). 2022 Nov 4:1-9. doi: 10.1080/15563650.2022.2138762. Epub ahead…
Question of the Day – Monday, January 16, 2023
In a systematic review evaluating fatal serotonin syndrome cases, what was the most common symptom experienced among patients? Hyperthermia Prakash S, Rathore C, Rana K, Prakash A. Fatal serotonin syndrome: a systematic review of 56 cases in the literature. Clin Toxicol (Phila). 2021 Feb;59(2):89-100. doi:…
Question of the Day – Friday, January 13, 2023
An evaluation of case reports of patients with neuroleptic malignant syndrome found that dantrolene monotherapy appears to be associated with? A higher incidence of mortality. Reulbach U, Dütsch C, Biermann T, Sperling W, Thuerauf N, Kornhuber J, Bleich S. Managing an effective treatment for neuroleptic…
Question of the Day – Thursday, January 12, 2023
Historical QOD 10/30/08: Name the most significant dose-dependent side effect of therapy with ethambutol. Optic or retrobulbar neuritis may be seen with high-dose ethambutol therapy, typically only after 1.5 months. Dyschromatopsia is often the earliest indicator of toxicity, with blue-yellow color changes being the most…
Question of the Day – Wednesday, January 11, 2023
In a retrospective review evaluating seizures associated with venlafaxine overdose, what percentage of patients experienced a seizure within 7-24 hours after ingestion? 25% Vo KT, Merriman AJ, Wang RC. Seizure in venlafaxine overdose: a 10-year retrospective review of the California poison control system. Clin Toxicol…
Question of the Day – Tuesday, January 10, 2023
1. A new diagnostic test (“Cyanotest”) is being evaluated to rapidly determine the presence of cyanide toxicity (Gold Standard: Whole blood cyanide concentration > 40 micromol/L)1 in patients who are house fire victims. All patients in the study have whole blood cyanide concentrations obtained upon…
Question of the Day – Monday, January 9, 2023
In a large cohort study examining the association of artificial sweetener intake and risk of cancer, what artificial sweetener had the highest associated risk of obesity-related and breast cancers? Aspartame Debras C, Chazelas E, Srour B, Druesne- Pecollo N, Esseddik Y, Szabo de Edelenyi F,…