Question of the Day – Wednesday September 1, 2021

Linamarin (2-hydroxyisobutylrnitrile-β- D-glucose) is the cyanogenic glycoside found in what type of plant? Unprocessed cassava root Consumed linamarin in unprocessed cassava root is hydrolyzed to cyanohydrin by intestinal β-glucosidases. Cyanohydrin then dissociates to cyanide in the alkaline environment of the small intestine. Chronic consumption of…

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Question of the Day – Tuesday August 31, 2021

How would you treat an inhalational exposure to americium-141 DTPA. DTPA can be given via nebulization or intravenously, with various factors contributing to this decision. The recommendation is to specifically administer Ca-DTPA as the first dose within the first 24 hrs after exposure and then…

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Question of the Day – Monday August 30, 2021

What drug when started at higher doses is associated with a higher 30-day risk of hospitalization with encephalopathy in older adults with CKD? Baclofen. A retrospective cohort study included 15,942 patients with CKD who were newly started on baclofen. The results showed that out of…

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Question of the Day – Friday August 27, 2021

Although the overall abuse rate is low, in eighth graders, the abuse of what product has increased from 1.6% in 2015 to 4.6% in 2020, an all time high? OTC cough medications containing dextromethorphan https://stopmedicineabuse.org/ Submitted by: Jennifer Splawski, PharmD, MS, BCPS

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Question of the Day – Thursday August 26, 2021

What were the most common adverse effects associated with Epidiolex in the Antiepileptic Efficacy Study of GWP42003-P (Cannabidiol) in Children and Young Adults With Dravet Syndrome? The more common side effects of cannabidiol were diarrhea, vomiting, fatigue, somnolence, lethargy and decreased appetite. Fever, upper respiratory…

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Question of the Day – Wednesday August 25, 2021

This novel therapy is being investigated as a potential treatment for carbon monoxide poisoning. Succinate prodrugs. The succinate prodrugs enhance delivery of succinate to cells and increase uptake of succinate into the mitochondria thereby providing metabolic support for cells. Jang DH et al. Emerging cellular…

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Question of the Day – Tuesday August 24, 2021

Reengineered neuroglobin is being investigated as a potential treatment for carbon monoxide poisoning. What is the half life of CO in human red blood cells treated with neuroglobin? 25 seconds. Azarov I et al. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning….

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Question of the Day – Monday August 23, 2021

What is Lytico-Bodig? Amyotrophic lateral sclerosis and Parkinsonism-dementia complex (ALS/PDC) is a complex neurodegenerative disease linked to dietary exposure to plants of the family Cycadaceae Ince PG, Codd GA. Return of the cycad hypothesis – does the amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) of Guam…

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Question of the Day – Friday August 20, 2021

Identify the plant and toxin. Cycas rumphii (Cycad). β-methylaminoalanine (BMAA) Ince PG, Codd GA. Return of the cycad hypothesis – does the amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health? Neuropathol Appl Neurobiol. 2005 Aug;31(4):345-53. doi: 10.1111/j.1365-2990.2005.00686.x. PMID: 16008818….

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Question of the Day – Thursday August 19, 2021

  Which neurotransmitter does ODAP (pictured above) most closely resemble? ODAP is a glutamic acid analogue Woldeamanuel YW, Hassan A, Zenebe G. Neurolathyrism: two Ethiopian case reports and review of the literature. J Neurol. 2012 Jul;259(7):1263-8. doi: 10.1007/s00415-011-6306-4. Epub 2011 Nov 12. PMID: 22081101. image…

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