Question of the Day – Friday July 31, 2020

In a simulated dialytic removal model, infusion of this drug resulted in the reduction of hemodialysis time to reach therapeutic concentration of carbamazepine from 265 to 220 minutes.   Maheshwari V et al. describes an innovative way to infuse a competitor drug into the extracorporeal…

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Question of the Day – Thursday July 30, 2020

In a recent prospective, cohort study of ED patients with drug overdose in a 5 year time frame, first-line push dose of this vasopressor was associated with higher in-hospital mortality?   According to Clifford C et al., patients who received push-dose phenlyephrine had a significantly…

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Question of the Day – Wednesday July 29, 2020

In a recent review, what was the incidence of Torsades des Pointes (TdP) in patients receiving droperidol?   Cole JB et al. performed a retrospective, observational cohort study from 1997-2001 in patients receiving parenteral droperidol for any indication. They found the incidence of TdP in…

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Question of the Day – Tuesday July 28, 2020

Concentrations of hydrogen sulfide of greater than 500 ppm are expected to cause what clinical effects?   Coma, cardiovascular collapse and pulmonary edema occur with hydrogen sulfide concentrations greater than 500 ppm. The classic rotten egg odor is identifiable at concentrations as low as 0.02…

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Question of the Day – Monday July 27, 2020

What were the most frequent reasons for medical evaluation in patients living in Martinique exposed to toxic gases of decompossing sargassum seaweed.   In a recent observational study performed in 2018 on the island of Martinique, patients most frequently reported neurologic, digestive and respiratory complaints….

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Question of the Day – Friday July 24, 2020

In a recent retrospective review of ciguatera poisoning reported to the French Poison Control Centers, 91% of patients with ciguatera poisoning after consuming fish from the Atlantic Ocean had nausea, vomiting, diarrhea and abdominal pain as their first symptoms. This was vastly different if the…

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Question of the Day – Thursday July 23, 2020

Increased occupational exposure to styrene increases the concentration of this metabolite found in the urine?   A recent study in 53 plastic injection workers by Mohamadyan M et al. revealed that increased occupational exposure to styrene increased mandelic acid concentrations in the urine. Mohamadyan M…

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Question of the Day – Wednesday July 22, 2020

The spur winged goose holds this toxin within its tissue?   The spur winged goose has a diet that includes ingestion of blister beetles. Cantharidin is held within the tissue of the fowl and can result in poisoning if ingested. Wikipedia. https://en.wikipedia.org/wiki/Spur-winged_goose. Accessed 24 June 2020

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Question of the Day – Tuesday July 21, 2020

A recent study suggests that B-oxidation inhibition may play a role in initiation of hepatotoxicity after this commonly used xenobiotic?   Ganetsky M et al. performed a metabolomic analysis of acetaminophen induced subclinical liver injury to attempt to determine the role of 2E1 inhibition on…

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Question of the Day – Monday July 20, 2020

“ZaZa” and “Tianna Red” are common names for this substance that has recently increased in use in the US?   Tianeptine is an antidepressant approved in some European countries with the trade names of Coaxil or Stablon. Over the past several years, tianeptine misuse and…

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