Question Of The Day

In a small retrospective case control study of patients with delusions of parasitosis, exposure to what medications was associated with the delusions? Patients with delusions of parasitosis were more commonly exposed to attention deficit disorder medications, selective serotonin reuptake inhibitors, opioids, and gabapentin, along with…

A study of 6101 adult cancer survivors showed the prevalence of active substance use disorder (SUD) was 3.83% (SE, 0.32%). In what types of cancer was the highest prevalence of SUD found? SUD was most prevalent in survivors of head and neck cancer (9.36% [SE,…

Historical QOD 2/27/2009: Cold allodynia (dysesthesia when touching cold water or cold objects) is characteristic of ingestion of fish containing what toxins? Ciguatoxins. Note that cold allodynia is often incorrectly termed “temperature reversal.” Isbister GK, Kiernan MC. Neurotoxic marine poisoning. Lancet Neurol. 2005 Apr;4(4):219-28. doi:…

In a study of patients who underwent spinal surgery, what medication was given during surgery that resulted in a 20% reduction of opiate use postoperatively compared to placebo? N-acetylcysteine was given at a dose of 150 mg/kg and resulted in a 20% decrease in opiate…

In a small study conducted in a Veterans Affairs hospital in Indianapolis, what was the most common way prescribers identified potential drug-drug interactions? 52% were detected by an alert in the electronic health record, 43% were identified independently by the prescriber themselves, and 5% were…

What is the estimated prognosis of neuropsychiatric symptoms associated with chronic nitrous oxide use in young patients treated with B12? What is the expected duration of drug exposure after ingestion of a “6-armed, star shaped drug delivery capsule?” 10 days Henrik Galust, et al. “Tianeptine…

What is the estimated prognosis of neuropsychiatric symptoms associated with chronic nitrous oxide use in young patients treated with B12? In a retrospective review of 16 patients aged 17-25, authors reporteed that neuropscyhatric symptoms resolved within 1-3 months Wu H, Xu L, Zheng X, Zhou…

Historical QOD 2/25/2009: From a toxicological perspective, what do pennyroyal, tansy, black cohosh root, blue cohosh root, cotton root bark, angelica root, rue, motherwort, and mandrake have in common? They have all enjoyed popularity throughout history as abortifacients Netland KE, Martinez J. Abortifacients: toxidromes, ancient…

In a prospective cohort study investigating the effect of xylazine in ED patients with suspected illicit opioid overdose, were clinical outcomes more or less severe in those testing testing positive for xylazine + illicit opioids vs. illicit opioids alone? Less severe. The primary outcome of…

In a recent article discussing phenibut withdrawal, what is the most commonly utilized medication class to help attenuate symptoms? Benzodiazepines Feldman, Ryan, Brian Autry, Joanna Dukes, Thomas Lofy, Gina Marchetti, Amber Patt, Nicole Batterman, and Jillian Theobald. “A Systematic Review of Phenibut Withdrawal Focusing on…