Question of the Day – Friday July 17, 2020

This laboratory finding was associated with deficits in episodic memory dysfunction in patients with acute organophosphate poisoning?   Complete RBC-AChE inhibition, compared to partial inhibition, was associated with deficits in episodic memory in patients that had acute organophosphate poisoning. These patients had poorer episodic memory…

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Question of the Day – Thursday July 16, 2020

This mitochondrial uncoupler recently was shown to reverse obesity and insulin resistance in mice.   BAM15 is a mitochondrial uncoupler, structurally unrelated to dinitrophenol, and in a recent mouse model was shown to be orally bioavailable and decreased body fat mass. In this model and…

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Question of the Day – Wednesday July 15, 2020

Performance and image enhancing drugs (“PIED”) are increasingly available and easily accessible online and on the black market. A recent analysis analyzed 400 products from samples confiscated in Italy over a 2 year period. What was the percentage of substances that had a qualitative analysis…

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Question of the Day – Tuesday July 14, 2020

In a recent retrospective analysis of fatal iatrogenic therapeutic errors reported to National Poison Data System, this group of drugs was responsible for the most number of cases?   In the recent review, specific medications were known in 171 out of 172 cases with cardiac…

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Question of the Day – Monday July 13, 2020

The FDA recently sent out an alert about a potential drug interaction with remdesivir and this drug?   On June 15, 2020 the Food and Drug Administration issued an alert about a potential drug interaction between remdesivir and hydroxychloroquine. The interaction may result in reduced…

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Question of the Day – Friday July 10, 2020

What is coturnism?   Coturnism is a rare cause of rhabdomyolysis after consumption of the European migratory quail. It is believed that a diet of hemlock seeds by the quail is the cause. (Korkmaz I et al. Quail consumption can be harmful. J Emerg Med…

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Question of the Day – Thursday, July 9, 2020

Methylene blue has been suggested as a treatment for refractory vasodilatory shock by limiting nitric oxide-mediate vasodilation. A recent porcine model compared the efficacy of norepinephrine versus methylene blue on mortality. Was methylene blue associated with decreased mortality?   In a recent porcine model, LeRoy…

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Question of the Day – Monday June 29, 2020

The peptides from the venom of this snake were isolated to develop the first ACEI, captopril.   Borhtrops jararaca, a South American viper, has peptides known to cause hypotension in its prey by inhibition of angiotensin converting enzyme. (https://www.pharmaceutical-journal.com/news-and-analysis/news/from-snake-venom-to-ace-inhibitor-the-discovery-and-rise-of-captopril/10884359.fullarticle?firstPass=false (Accessed 3 June 2020)) *The Envenomations…

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Question of the Day – Friday June 26, 2020

Elevated bilirubin concentrations may result in a false elevation of this laboratory test?   High bilirubin concentrations have resulted in falsely elevated acetaminophen levels when the acetaminophen level is performed utilizing an enzymatic assay. (Beuhler M et al. False Positive Acetaminophen Levels Associated with Hyperbilirubinemia….

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Question of the Day – Thursday June 25, 2020

Naproxen’s metabolite can cause a false elevation in this common laboratory test?   Naproxen’s metabolite can cause falsely elevated bilirubin when measured by Jendrassik and Grof method. (Dasgupta A et al. Naproxen metabolites interfere with certain bilirubin assays: elimination of interference by using a roche…

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