Historical QOD 4/27/24: Nitrous oxide is capable of oxidizing the cobalt atom in the vitamin B12 molecule resulting in an irreversible inhibition of methionine synthase. This mechanism may result in the development of a myeloneuropathy in individuals exposed to nitrous oxide. What profession is most commonly associated with occupational exposure to nitrous oxide and the consequent risks for myeloneuropathy?
Dentists and dental professionals who administer (or abuse) nitrous oxide.
Meyers L, Judge B,Clinical Toxicology 2008, 46:1095-1096
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