How did patients with co-ingestion of gamma hydroxybutyrate compare with patients with co-ingestion of benzodiazepines in methamphetamine exposure cases described in a 2024 publication?
Patients who presented with co-ingestions of gamma hydroxybutyrate had a significantly higher serum concentration of methamphetamine but lower presenting heart rate and body temperature when compared to benzodiazepine co-ingestions.
Greene, S. L., Syrjanen, R., Hodgson, S. E., Abouchedid, R., & Schumann, J. (2024). Co-exposure to gamma-hydroxybutyrate is associated with attenuated neuropsychiatric and stimulant effects of metamfetamine. Clinical Toxicology, 62(5), 303–313. https://doi.org/10.1080/15563650.2024.2353265
Contributed by Herbert Wan, PharmD, PGY1 Toxicology/Emergency Medicine Fellow, FL/USVI Poison Information Center Jacksonville