Question of the Day – Thursday August 6, 2020

This chemical is the newest synthetic opioid to emerge on the illicit drug markets. In vitro data suggests that it has similar potency as fentanyl. It has appeared in both the US and Europe.   NPS Discovery reported that Brorphine has recently been identified in…

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Question of the Day – Wednesday August 5, 2020

What is the overall survival of poisoned patients supported with ECMO?   Cole JB et al. recently reported results of their recent retrospective cohort study of NPDS data from 2000 through 2018 of poisoned patients supported with ECMO. In this cohort, there was a 70%…

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Question of the Day – Tuesday August 4, 2020

What is Lhermitte’s sign, and what toxin induced clinical syndrome is it associated with?   Lhermitte’s sign is a clinical finding associated with flexion of the head resulting in a shower of parasthesia sensation through the upper and lower extremities. It is typically associated with…

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Question of the Day – Monday August 3, 2020

What is Rossolimo’s sign, and chronic abuse of which drug is it associated with?   Rossolimo’s sign is a physical examination finding where percussion of the tips of the toes results in exaggerated flexion of the toes. It has been reported in association with nitrous…

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Question of the Day – Friday July 31, 2020

In a simulated dialytic removal model, infusion of this drug resulted in the reduction of hemodialysis time to reach therapeutic concentration of carbamazepine from 265 to 220 minutes.   Maheshwari V et al. describes an innovative way to infuse a competitor drug into the extracorporeal…

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Question of the Day – Thursday July 30, 2020

In a recent prospective, cohort study of ED patients with drug overdose in a 5 year time frame, first-line push dose of this vasopressor was associated with higher in-hospital mortality?   According to Clifford C et al., patients who received push-dose phenlyephrine had a significantly…

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Question of the Day – Wednesday July 29, 2020

In a recent review, what was the incidence of Torsades des Pointes (TdP) in patients receiving droperidol?   Cole JB et al. performed a retrospective, observational cohort study from 1997-2001 in patients receiving parenteral droperidol for any indication. They found the incidence of TdP in…

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Question of the Day – Tuesday July 28, 2020

Concentrations of hydrogen sulfide of greater than 500 ppm are expected to cause what clinical effects?   Coma, cardiovascular collapse and pulmonary edema occur with hydrogen sulfide concentrations greater than 500 ppm. The classic rotten egg odor is identifiable at concentrations as low as 0.02…

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Question of the Day – Monday July 27, 2020

What were the most frequent reasons for medical evaluation in patients living in Martinique exposed to toxic gases of decompossing sargassum seaweed.   In a recent observational study performed in 2018 on the island of Martinique, patients most frequently reported neurologic, digestive and respiratory complaints….

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Question of the Day – Friday July 24, 2020

In a recent retrospective review of ciguatera poisoning reported to the French Poison Control Centers, 91% of patients with ciguatera poisoning after consuming fish from the Atlantic Ocean had nausea, vomiting, diarrhea and abdominal pain as their first symptoms. This was vastly different if the…

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