Administrator Clintox - One

In a recent phase II clinical trial evaluating psilocybin in the management of treatment resistant major depression, what were the severe adverse events reported? Goodwin GM et al. performed a double-blind trial to compare the change from baseline to week 3 of the total score…

What is the IARC classification for benzene and which malignancies has it been associated with? “There is sufficient evidence in humans for the carcinogenicity of benzene. Benzene causes acute myeloid leukaemia/acute non-lymphocytic leukaemia. Also, a positive association has been observed between exposure to benzene and…

Historical QOD 10/22/08: Describe signs and symptoms of camphor intoxication. Camphor intoxication can involve nausea/vomiting, burning of the mouth/throat, and cyanosis of the lips in severe cases. Neurologic symptoms predominate, and include irritability, hyper-reflexia, tonic muscular contraction, myoclonic jerks, confusion, coma, and apnea. Seizures are…

A recent recall on dry-shampoo was based on the potential presence of elevated levels of which chemical? Benzene. https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/unilever-issues-voluntary-us-recall-select-dry-shampoos-due-potential-presence-benzene

A worker in a chemical dye manufacturing facility develops urothelial cell bladder cancer. This facility likely produces which of the following colors/dyes? A. Basic Magenta. Basic Magenta (CAS: 632-99-5, IUPAC – 4-[(4-aminophenyl)-(4-imino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]aniline;hydrochloride) is a component of Magenta dye. Production of Magenta may involve exposure to…

What medications has been shown in animal and in-vitro models to prevent fluoride induced hyperkalemia? Amiodarone and Quinidine. A study by Su M et al. used an in-vitro model of human blood and showed that both amiodarone and quinidine attenuated fluoride induced hyperkalemia. Su M…

What species of buffalobish is most recently associated with Haff disease? Deeds JR et al. recently investigated cases of Haff disease between 2010 and 2020 in the US. 16 of the 24 samples tested identifed I. bubalus. This is contrary to previous reports that I….

Historical QOD 10/21/08: Describe the pathophysiology involving scorpion envenomation by Centroides exillicauda. C. exillicauda venom consists of primarily neurotoxins causing sodium channel opening at neuromuscular junctions. Repetitive depolarization subsequently occurs in both the sympathetic and parasympathetic nervous system, causing simultaneous acetylcholine and catecholamine surges. (Rimsza…

Which drug is pictured below? Sodium Nitroprusside https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-nitroprusside

What is the management of children with exposures to direct oral anticoagulants (DOACs)? What are the expected outcomes among children? Are specific reversal agents (idarucizumab or andexanet alfa) indicated? A recent systematic review recommends observation and supportive care (which may include oral activated charcoal within…