Co-ingestion of what xenobiotic is associated with an increased risk of MALA when compared with metformin ingestion alone?
In a retrospective observational cohort study of ED patients presenting with acute drug overdose, acetaminophen co-exposure was associated with over a 24-fold increased risk of MALA when compared with metformin ingestion alone.
Taub ES, Hoffman RS, Manini AF. Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. Am J Emerg Med. 2019;37(12):2205-2208. doi:10.1016/j.ajem.2019.03.033
Submitted by: Kirk Cumpston, DO, FAACT