Question Of The Day

Dermal and gastric decontamination with what solution is recommended for phenol exposures? Animal models have shown decreased mortality, systemic effects, and dermal burns after using low molecular weight polyethylene glycol (PEG) compared to water. Brown VK, Box VL, Simpson BJ. Decontamination procedures for skin exposed…

In a review of acute metformin overdose, what percentage of people died with a nadir pH less than 6.9 and lactate greater than 25 mmol/L? 83% Dell’Aglio DM, Perino LJ, Kazzi Z, Abramson J, Schwartz MD, Morgan BW. Acute metformin overdose: examining serum pH, lactate…

Under what circumstances might DDMAPh (100 mg digoxin, 1,000 mg diazepam, 15,000 mg morphine, 8,000 mg amitriptyline, 5,000 mg phenobarbital, mixed in 4 ounces of water) be prescribed for a patient? DDMAPh is the primary medication combination used for Medical Aid in Dying. 30 minutes…

In a recent retrospective analysis, these two biomarkers were elevated in patients with liver failure secondary to mushroom poisoning? Lactate and ammonia. Gao Y et al. Lactate and blood ammonia on admission as biomarkers to predict the prognosis of patients with acute mushroom poisoning and…

Linamarin (2-hydroxyisobutylrnitrile-β- D-glucose) is the cyanogenic glycoside found in what type of plant? Unprocessed cassava root Consumed linamarin in unprocessed cassava root is hydrolyzed to cyanohydrin by intestinal β-glucosidases. Cyanohydrin then dissociates to cyanide in the alkaline environment of the small intestine. Chronic consumption of…

How would you treat an inhalational exposure to americium-141 DTPA. DTPA can be given via nebulization or intravenously, with various factors contributing to this decision. The recommendation is to specifically administer Ca-DTPA as the first dose within the first 24 hrs after exposure and then…

What drug when started at higher doses is associated with a higher 30-day risk of hospitalization with encephalopathy in older adults with CKD? Baclofen. A retrospective cohort study included 15,942 patients with CKD who were newly started on baclofen. The results showed that out of…

Although the overall abuse rate is low, in eighth graders, the abuse of what product has increased from 1.6% in 2015 to 4.6% in 2020, an all time high? OTC cough medications containing dextromethorphan https://stopmedicineabuse.org/ Submitted by: Jennifer Splawski, PharmD, MS, BCPS

What were the most common adverse effects associated with Epidiolex in the Antiepileptic Efficacy Study of GWP42003-P (Cannabidiol) in Children and Young Adults With Dravet Syndrome? The more common side effects of cannabidiol were diarrhea, vomiting, fatigue, somnolence, lethargy and decreased appetite. Fever, upper respiratory…

This novel therapy is being investigated as a potential treatment for carbon monoxide poisoning. Succinate prodrugs. The succinate prodrugs enhance delivery of succinate to cells and increase uptake of succinate into the mitochondria thereby providing metabolic support for cells. Jang DH et al. Emerging cellular…