Question Of The Day

What was the most common clinical effect in patients insufflating bupropion? In a recent retrospective review by McCabe et al., tachycardia occured in 53.6% of patients and was the most common effect noted. McCabe DJ et al. The Timing of Clinical Effects of Bupropion misuse…

How common are seizures after insufflation of bupropion? In a recent retrospective review of a single poison center data, seizures occured in 19.6% of patients. MCabe DJ et al. The Timing of Clinical Effects of Bupropion misuse via insufflation reported to a regional poison center….

In a recent paper, what topical salicylate product was associated with the most pediatric hospitalizations following ingestion? Although hospitalization and supratherapeutic salicylate concentrations were very uncommon (1%), oil of wintergreen products were associated with the highest salicylate concentrations. Arriola K, Cantrell L. Rick of toxicity…

What advantage has a 2 bag NAC model shown over the traditional 3 bag NAC model? O’Callaghan et al. showed that a two bag NAC regimen was associated with shorter delays (30 minutes) and interruptions compared to the traditional 3 bag regimen. O’Callaghan C et…

What happens to circulating microRNA-122 (miR-122) in patients with non-toxic acute acetaminophen ingestions? In a recent observational study of 10 patients with an acute ingestion of acetaminophen that had a 4-hour concentration below the Rumack-Matthew nomogram line, there was no difference in miR-122 in patients…

What are the three predictors of death in paraquat poisoning used to create the acute paraquat poisoning mortality (APPM) score? Chen CK et al., using a 10 year observational cohort study, found that urine paraquat concentrations (> 10 ppm), serum glucose (> 140 mg/dL) and…

What class of drugs was responsible for the majority of fatal poisonings in children aged 0-9 years? In a recent retrospective analysis of fatal poisonings from 2012 to 2017, 7% of deaths (n=122) were poisoning-related with 50% of these deaths attributed to opioids. Hunter AA…

An uncommon, severe form of hypernatremia called salt toxicity can occur after ingestion of a massive single dose of table salt over minutes to hours. Salt toxicity requires immediate medical attention due to its high mortality and potential neurological injury that can be permanent. What…

Chloropicrin is a volatile and reactive chemical which has been used as a warfare agent and pesticide. Its toxicity mainly affects the respiratory system where lung irritation, inflammation, and pulmonary edema can result if inhaled. Chloropicrin breaks down into what chemical that evokes similar symptoms…

What is Pibloktoq? Pibloktoq, or “Artic Hysteria” is a “culture bound syndrome” of behavioral disturbance that has been proposed to have origins in environmental, nutritional, and psychological origins. The author of the cited refrence argues that cultural or social factors may be the true origin…