In a review of acute metformin overdose, what percentage of people died with a nadir pH less than 6.9 and lactate greater than 25 mmol/L?
83%
Dell’Aglio DM, Perino LJ, Kazzi Z, Abramson J, Schwartz MD, Morgan BW. Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature. Ann Emerg Med. 2009 Dec;54(6):818-23. doi: 10.1016/j.annemergmed.2009.04.023. Epub 2009 Jun 25. PMID: 19556031.
Submitted by: Andrew Chambers, DO, MS on behalf of The Medical Toxicology Fellowship, Virginia Commonwealth University
Posted in Question Of The Day