Through what mechanism is vasoplegia theorized to occur in amlodipine overdose patients receiving high dose insulin infusions?
Synergistic induction of eNOS by both amlodipine and HDI therapy
Cole JB, Lee SC, Prekker ME, et al. Vasodilation in patients with calcium channel blocker poisoning treated with high-dose insulin: a comparison of amlodipine versus non-dihydropyridines. Clin Toxicol (Phila). 2022;60(11):1205-1213. doi:10.1080/15563650.2022.2131565
Contributed by Jacob Sammon, MD, PGY2 Emergency Medicine Resident, UF Health Jacksonville on behalf of the Florida Poison Information Center Network
Posted in Question Of The Day