Administrator Clintox - One

What was the primary exposure reason for calls to US poison centers involving cannabis in women aged 50 or older? Therapeutic errors/adverse reactions. A retrospective study of NPDS data from 2009-2019 identified 3633 exposures in patients aged 50 or older with cannabis as the primary…

When did cardiac arrest or sudden unexpected deaths occur following intramuscular injection of long-acting paliperidone palmitate? 10-14 days after injection of the one-month formulation or 11-24 days after injection of the three-month formulation. A review of 473 adverse drug reactions reported to the French pharmacovigilance…

What changes were identified in call volumes to French poison control centers during the COVID-19 pandemic? Overall, a 5.6% increase in exposure calls with 13.6% increase in calls from the public and a 7.5% decrease in calls from health professionals. Call volumes for March/April of…

What was the incidence of hepatotoxicity in patients with “massive” acetaminophen overdose treated with standard dose IV N-acetylcysteine? 24%. A retrospective study of acetaminophen exposures reported to a regional poison center identified 104 cases of massive overdose (4-hour level > 300 mcg/mL). Only 4% of…

What common household cooking product can lead to significant ethanol intoxication which may require hospitalization when ingested? Pure vanilla extract. According to the FDA standard, natural vanilla extract must contain a minimum of 35% ethanol by volume. Ingestion of 1.3mL/kg of pure vanilla extract in…

A 7-year-old boy presented to the hematology–oncology clinic for treatment of severe aplastic anemia. What drug lead to gum hypertrophy shown in this photo? Cyclosporine. Several months after cyclosporine was started gum hypertrophy developed. When cyclosporine was weaned off, the adverse effect resolved. Two years…

This drug recently was shown to cause a mean weight loss of 14.9% from baseline over a 68 week time period. Semaglutide 2.4 mg once weekly resulted in a mean weight loss of 14.9% from baseline with lifestyle interventions in a recent study over a…

In a retrospective study comparing those treated with cyproheptadine and without for serotonin syndrome in California over eleven years, patients who were intubated and sedated were more likely to receive cyproheptadine, but was there a difference in serious outcome or hospitalization? No. The odds ratio…

This antibiotic is a potent inhibitor of organic anion transporting polypeptide B3 (OAPTB3) transporter of amatoxin into human hepatocytes. Rifampicin. Both rifampicin and high dose penicillin G have been shown in in vitro studies to be inhibitors of OAPTB3 transporter and in one study, rifampicin…