Question of the Day – Monday March 15, 2021
What is the antidote for a patient with severe cytokine release syndrome (CRS) after treatment with CAR-T? Tocilizumab. It is a humanized monoclonal antibody that competitively inhibits binding of IL-6 to its receptor. It is indicated for any CRS grade above 2. CARTOX is a…
Question of the Day – Friday March 12, 2021
Name 3 CAR-T products that are currently approved by the FDA ? Tisagenlecleucel for patients 25 years and younger with refractory ALL AND for adults with relapses/refractory diffuse large b-cell lymphoma; Axicabtagene ciloleucel for adult patients with diffuse large b-cell lymphoma; Brexucabtagene autoleucel for adults…
Question of the Day – Thursday March 11, 2021
Toxicity with which substance is responsible for causing “gasping syndrome” in neonates? Benzyl Alcohol. Benzyl alcohol is an aromatic alcohol that is oxidized to benzoic acid, conjugated in the liver with glycine, and excreted in the urine as hippuric acid. This process required for the…
Question of the Day – Wednesday March 10, 2021
A 34 week-gestation infant was delivered from a mother with bipolar disease and PTSD on a combination of venlafaxine 150 mg daily, bupropion hydrochloride 300 mg daily, quetiapine 200 mg daily, and gabapentin 1200 mg 3 times daily. What symptoms did the infant experience and…
Question of the Day – Tuesday March 9, 2021
In a cohort of overdose patients admitted to two hospitals in northwestern France in the past decade, the authors compared survival among critically ill patients with and without extracorporeal life support (ECLS). How many of the patients with persistent cardiac arrest survived without ECLS? 0%….
Question of the Day – Monday March 8, 2021
A recent study of non-fatal drug-related overdoses in youths reported from the CDC’s National Syndromic Surveillance System Biosense Program from 2016 to 2019 showed what trends for heroin and stimulants? Suspected heroin overdoses decreased by an average of 3.3% per quarter for youth aged 15…
Question of the Day – Friday March 5, 2021
In a recent retrospective analysis of seizures due to venlafaxine overdose, how common did patients with venlafaxine overdose have a seizure? The California Poison Center System (CPCS) retrospectively reviewed 10 years of venlafaxine exposures. During the time frame of the study, 953 patients who ingested…
Question of the Day – Thursday March 4, 2021
In a recent porcine model of carbon monoxide poisoning, the lactate to pyruvate ratio was elevated compared to the control group. What do the authors hypothesize this is due to? The lactate/pyruvate ratio (LPR) is often an indication of dysfunction within the electron transport chain…
Question of the Day – Wednesday March 3, 2021
This laboratory test appears to be prognostic of mortality in calcium channel blocker poisoning. Serum lactate. In a recent retrospective review of 177 patients, presented at EAPCCT 2020, initial blood lactate concentration accurately predicted CCB-poisoning related mortality. In this study, initial blood glucose concentrations was…
AACT, AAPCC and ACMT Release Joint Statement of Caution Regarding Use of Colchicine for Treatment of COVID-19
Joint Statement of Caution on Colchicine