August Message from AACT’s President, Dr. Kirk Cumpston
August 27, 2021 Well…there is a light at the end of this pandemic, but we are not quite there yet. The FDA approved vaccine combined with mandates and preventive efforts to slow the spread of the delta variant is coming just in time to counteract…
Question of the Day – Friday August 27, 2021
Although the overall abuse rate is low, in eighth graders, the abuse of what product has increased from 1.6% in 2015 to 4.6% in 2020, an all time high? OTC cough medications containing dextromethorphan https://stopmedicineabuse.org/ Submitted by: Jennifer Splawski, PharmD, MS, BCPS
Next AACT Section Webinar scheduled for September 9, 2021 at 1:00 pm Eastern
Question of the Day – Thursday August 26, 2021
What were the most common adverse effects associated with Epidiolex in the Antiepileptic Efficacy Study of GWP42003-P (Cannabidiol) in Children and Young Adults With Dravet Syndrome? The more common side effects of cannabidiol were diarrhea, vomiting, fatigue, somnolence, lethargy and decreased appetite. Fever, upper respiratory…
Question of the Day – Wednesday August 25, 2021
This novel therapy is being investigated as a potential treatment for carbon monoxide poisoning. Succinate prodrugs. The succinate prodrugs enhance delivery of succinate to cells and increase uptake of succinate into the mitochondria thereby providing metabolic support for cells. Jang DH et al. Emerging cellular…
Question of the Day – Tuesday August 24, 2021
Reengineered neuroglobin is being investigated as a potential treatment for carbon monoxide poisoning. What is the half life of CO in human red blood cells treated with neuroglobin? 25 seconds. Azarov I et al. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning….
Question of the Day – Monday August 23, 2021
What is Lytico-Bodig? Amyotrophic lateral sclerosis and Parkinsonism-dementia complex (ALS/PDC) is a complex neurodegenerative disease linked to dietary exposure to plants of the family Cycadaceae Ince PG, Codd GA. Return of the cycad hypothesis – does the amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) of Guam…
Question of the Day – Friday August 20, 2021
Identify the plant and toxin. Cycas rumphii (Cycad). β-methylaminoalanine (BMAA) Ince PG, Codd GA. Return of the cycad hypothesis – does the amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health? Neuropathol Appl Neurobiol. 2005 Aug;31(4):345-53. doi: 10.1111/j.1365-2990.2005.00686.x. PMID: 16008818….
Question of the Day – Thursday August 19, 2021
Which neurotransmitter does ODAP (pictured above) most closely resemble? ODAP is a glutamic acid analogue Woldeamanuel YW, Hassan A, Zenebe G. Neurolathyrism: two Ethiopian case reports and review of the literature. J Neurol. 2012 Jul;259(7):1263-8. doi: 10.1007/s00415-011-6306-4. Epub 2011 Nov 12. PMID: 22081101. image…
Question of the Day – Wednesday August 18, 2021
What is a typical clinical course of neurolathyrism? According to the cited reference, a typical course starts 3-6 months after a diet of 30% of the seeds. Three clinical courses have been described as acute, subacute, and insidious. Most commonly, sudden onset of dramatic bilateral…