Question of the Day – Friday, March 3, 2023
Based on this recent retrospective study of synthetic cannabinoid exposures correlating with cannabis legality, what was the trend towards states with restrictive and permissive cannabis legalization? Majority (56%) of synthetic cannabinoid exposures occurred in states with more restrictive cannabis policies compared to 5.5% exposure in…
Question of the Day – Thursday, March 2, 2023
Historical QOD 11/13/08: What is the most serious complication of ingestion of Ginkgo biloba seeds, what is the compound responsible for this effect, and what is the recommended treatment? Seizures following ingestion of Ginkgo biloba seeds appear to be caused by 4-methoxypyridoxine (MPN) and should…
Question of the Day – Wednesday, March 1, 2023
In a recent retrospective review of 107 suspected beta-blocker toxicity, how much of an effect was glucagon found to have on heart rate (HR) and systolic blood pressure (SBP)? Glucagon (mean dose = 2.66mg) was associated with a statistically significant increase in both HR (mean…
Question of the Day – Tuesday, February 28, 2023
When comparing US cases of EVALI with those published outside of the US, what differences were noted? EVALI case reports published from outside the US had a higher number of patients reporting vaping liquid nicotine products, where as those published from within the US had…
Question of the Day – Monday, February 27, 2023
What is the utility of dialysis in the setting of intentional ingestion of Yew leaves? Due to its pharmacokinetic characteristics of high volume of distribution, molecular weight, and protein binding, Taxine B is not effectively removed by hemodialysis. Buetler VA, Braunshausen AM, Weiler S, Klukowska-Rötzler…
Question of the Day – Friday, February 24, 2023
What is the cardiotoxic component of Taxus Baccata? Taxine B has Na and Ca channel inhibition that can result in life threatening dysrythmia after ingestion. Buetler VA, Braunshausen AM, Weiler S, Klukowska-Rötzler J, Exadaktylos AK, Liakoni E. Characteristics of emergency department presentations following ingestion of…
Question of the Day – Thursday, February 23, 2023
Historical QOD 11/12/08: What are the poisonous constituents of horse chestnuts? Ingestion of horsechestnut has been associated with GI illness, esculins in the saponin fraction of the horse chestnut are thought to be responsible by increasing GIT in a dose dependent manner. Matsuda H, Li…
Question of the Day – Wednesday, February 22, 2023
What type of occular toxicity poses an occupational exposure for industrial mercury battery workers? Ocular findings in patients with chronic exposure to mercury are: discoloration of the cornea and lens, tremor of the eyelids, disturbances of vision and of extraocular muscles, and in very young…
Question of the Day – Tuesday, February 21, 2023
Under the proposed definition based on review of 40 cases, what consitutes a confirmed case of Opioid Associated Amnesia? New onset amnesia greater than 24 hours in duration AND positive toxicology for an opioid AND bilateral hippocampal injury on CT or MRI Barash JA, Whitledge…
Question of the Day – Monday, February 20, 2023
In addition to progressive encephalopathy, what ocular toxicity is associated with fludarabine? Fludarabine is a purine analog used to treat lymphoid malignancies and has been associated with cortical blindness. Ding X, Herzlich AA, Bishop R, Tuo J, Chan CC. Ocular toxicity of fludarabine: a purine…