Administrator Clintox - One

Historical QOD 11/12/08: What are the poisonous constituents of horse chestnuts? Ingestion of horsechestnut has been associated with GI illness, esculins in the saponin fraction of the horse chestnut are thought to be responsible by increasing GIT in a dose dependent manner. Matsuda H, Li…

What type of occular toxicity poses an occupational exposure for industrial mercury battery workers? Ocular findings in patients with chronic exposure to mercury are: discoloration of the cornea and lens, tremor of the eyelids, disturbances of vision and of extraocular muscles, and in very young…

Under the proposed definition based on review of 40 cases, what consitutes a confirmed case of Opioid Associated Amnesia? New onset amnesia greater than 24 hours in duration AND positive toxicology for an opioid AND bilateral hippocampal injury on CT or MRI Barash JA, Whitledge…

In addition to progressive encephalopathy, what ocular toxicity is associated with fludarabine? Fludarabine is a purine analog used to treat lymphoid malignancies and has been associated with cortical blindness. Ding X, Herzlich AA, Bishop R, Tuo J, Chan CC. Ocular toxicity of fludarabine: a purine…

How much oxygen is liberated from 1 mL of 30% hydrogen peroxide? “1 mL of 35% (v/v) hydrogen peroxide releases 100 mL oxygen” Mullins ME, Beltran JT. Acute cerebral gas embolism from hydrogen peroxide ingestion successfully treated with hyperbaric oxygen. J Toxicol Clin Toxicol. 1998;36(3):253-6….

Historical QOD 11/11/08: What ear malformations are typically seen in children whose mothers took isotretinoin during pregnancy? Partial duplications and tissue reductions and displacements Hall BK. Summarizing craniofacial genetics and developmental biology (SCGDB). Am J Med Genet A. 2014 Apr;164A(4):884-91. doi: 10.1002/ajmg.a.35288. Epub 2014 Jan…

What simple technique can be employed to differentiate the composition of an unidentified mothball (camphor vs naphthalene vs paradichlorobenzene)? Each substance has a distinct specific gravity, allowing mothballs to be differentiated based on buoyancy (camphor=0.992, naphthalene=1.15, paradichlorobenzene=1.30). Camphor-containing mothballs will float in water while both…

In a recent metanalysis of studies examining whether the paracetamol x transferase multiplication product predicted hepatotoxicity after paracetamol overdose, the authors analyzed 5,036 participants as an entire group and as subgroups. This product was particularly helpful in ruling out hepatotoxicity in which presentation: single acute…

What is a proposed mechanism of cyclosporine as a potential treatment for amatoxin-poisoned patients? MacKenzie CA et al. reported a small case series of cyclosporine as a novel treatment for amatoxin containing mushroom poisonings. Cyclosporine, in vitro, completely inhibited OATP1B3-mediated cellular uptake of alpha-amanitin. MacKenzie…

This element (atomic number 20) is frequently used as a PVC stabilizer, pigment, neutron absorber in power plants, component of battery manufacturing, and anticorrosive agent. It can lead to a terrible pneumonitis, forms a complex with metallothionein and ultimately ends up filtered by the glomerulus…