What is a proposed mechanism of cyclosporine as a potential treatment for amatoxin-poisoned patients?
MacKenzie CA et al. reported a small case series of cyclosporine as a novel treatment for amatoxin containing mushroom poisonings. Cyclosporine, in vitro, completely inhibited OATP1B3-mediated cellular uptake of alpha-amanitin.
MacKenzie CA et al. Cyclosporine as a novel treatment for amatoxin-containing mushroom poisonings: a case series. Toxicology Communications 2022; 6:1:23-27.