Question Of The Day

In a recent case report of a 54 year old male, what was the adverse effect associated with the administration of hydroxocobalamin? Hydroxocobalamin-induced oxalate nephropathy Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep….

In patients with smoke inhalation injury admitted to the ICU what factors were associated with mortality in ICU in this retrospective analysis? Age, severe burns, admission plasma lactate, and SAPS2 Dépret F, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation:…

In a review of pooled cases of diphenhydramine toxicity refractory to traditional resuscitation methods, which parameters showed improvement after lipid emulsion therapy? In the patients who received LET, the mean arterial pressure (MAP) increased in MAP 37±17.5mm Hg compared to a decrease by 4.5 ±…

In the RCT looking at High dose ILE, what factor(s) led the authors to question the idea of Intralipids role in “lipid sink compartment” model? 1) RCT exhibited gradual/modest hemodynamic effects from the use of  ILE infusion alone.  which contrasts case reports,in which, rapid onset…

In patients suffering from thiocyanate toxicity, what sort of treatment options are available for the unstable patient? Lipid emulsion therapy may be a suitable therapy option in patients suffering from thiocyanate toxicity as the molecule is lipid soluble. Furthermore, hemodialysis can be considered in patients…

In the randomized controlled study comparing high- dose insulin to vasopressors or combination therapy in a porcine model of refractory propranolol-induced cardiogenic shock, why was it important to maintain a MAP of greater than 55 mmHg? In humans, the literature suggests that cerebral blood flow…

According to the paper by Graudins and Druda, what effects on the heart has levosimendan shown in animal models in cases of calcium channel blocker and beta-blocker toxicity? Increases cardiac output without increasing blood pressure 2Graudins A, Lee HM, Druda D. Calcium channel antagonist and…

Name two substances that can potentially lead to a false elevation in serum salicylate concentration? Dinitrophenol; Thiocyanate 1.Kopec KT et al. Dinitrophenol Fatality Associated with a Falsely Elevated Salicylate Level: A case Report with Verification of laboratory cross reactivity. JMT 2018; 14(4): 323-326 ; 2….

A 36 yo male presents to the ED in Turkey with complaints of weakness, muscle pain and dark urine. What did he ingest? Quail meat. Coturnix coturnix coturnix is a small migratory quail and toxicity is associated with the European subspecies. Consumption of these birds…

This pigeon is known to acquire monofluoracetate. The Bronzewings (Phaps elegans and Phaps chalcoptera) are medium sized pigeons native to Australia. Yeung KA et al. Avian Toxins and Poisoning Mechanisms. JMT 2022. Published online 26 April 2022.