According to the paper by Graudins and Druda, what effects on the heart has levosimendan shown in animal models in cases of calcium channel blocker and beta-blocker toxicity?
Increases cardiac output without increasing blood pressure
2Graudins A, Lee HM, Druda D. Calcium channel antagonist and beta-blocker overdose: antidotes and adjunct therapies. Br J Clin Pharmacol. 2016 Mar;81(3):453-61
Contributed by: Dawn Sollee, PharmD DABAT & Molly Stott, PharmD on behalf of Florida/USVI Poison Information Center-Jacksonville