Question Of The Day

This ratio of CBD/THC has been suggested to be helpful when differentiating between marijuana use from consumption of commercial CBD Products?   10:1 CBD/THC. Goggin MM et al. developed an LC–MS/MS method for the quantitation of CBD, 7-COOH-CBD, THC, and 11-COOH-THC in urine was developed…

What is the toxic component in the European elderberry?   Sambunigrin which is a cyanogenic glycoside. Buhrmester Ra et al. Sambunigrin and cyanogenic variability in populations of Sambucus canadensis L. (Caprifoliaceae). Biochemical Systematics and Ecology 2000; 28(7): 689-695.

What was the most commonly reported symptom in patients exposed to liquid laundry detergent packets?   Vomiting. A retrospective review of 18 months exposures reported to US poison centers identified over 13,000 cases involving liquid laundry detergent packets followed to a known outcome. Approximately 89%…

What were the most commonly reported symptoms in case reports of fatal serotonin syndrome?   Fever (61%), seizure (36%), and tremors (30%). A systematic review of published cases reporting fatalities from serotonin syndrome identified 56 patients. Temperature was reported in 25 patients with an average…

How are infants most commonly exposed to ethanol?   Mixing of alcohol into formula (38.6%) and breast milk (18.9%). A retrospective review of ethanol exposures in infants (< 12 months) identified 70 cases reported to two US poison centers over a period of 10 years….

What is the mechanism of action of the toxin extracted from the seeds of this plant?   Ricin inhibits protein synthesis by catalyzing the cleavage of a specific adenine residue of 28S ribosomal RNA. Lord JM, Roberts LM, Robertus JD. Ricin: structure, mode of action,…

Name the structure, its primary metabolite in humans, and the plant source   Cocaine, benzoylecogonine, erythroxylum coca Pubchem.org

For which rodenticide has nicotinamide been a suggested antidote, and by which mechanism?   Pyriminil, Pyrinuron, PNU, Vacor. Vacor metabolism in sensitive cells results in Vacor adenine dinucleotide (VAD). VAD is an NAD analog that impairs NAD production resulting in cell death. Buonvicino D, Mazzola…

Ingestion of the roots, leaves, and fruits of hyoscyamus niger can lead to what typical poisoning syndrome? Atropine poisoning. The roots, leaves, and fruit of hyoscyamus niger contain alkaloids such as atropine, hyoscyamine, and scopolamine, leading to a syndrome similar to atropine poisoning with symptoms…

For which rodenticide has ethanol been a suggested antidote, and by which mechanism?   Sodium mono-fluoroacetate (SMFA) (1080). Ethanol is metabolized Acetaldehyde and then to acetyl CoA which is thought to compete with SMFA for citrate synthase, the site of toxicicity of suicide inhibition by…