For which rodenticide has nicotinamide been a suggested antidote, and by which mechanism?
Pyriminil, Pyrinuron, PNU, Vacor. Vacor metabolism in sensitive cells results in Vacor adenine dinucleotide (VAD). VAD is an NAD analog that impairs NAD production resulting in cell death.
Buonvicino D, Mazzola F, Zamporlini F, Resta F, Ranieri G, Camaioni E, Muzzi M, Zecchi R, Pieraccini G, Dölle C, Calamante M, Bartolucci G, Ziegler M, Stecca B, Raffaelli N, Chiarugi A. Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites. Cell Chem Biol. 2018 Apr 19;25(4):471-482.e7. doi: 10.1016/j.chembiol.2018.01.012. Epub 2018 Feb 22. PMID: 29478906.
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