January Message from AACT President, Dr. Kirk Cumpston
January 31, 2022 We just unwrapped 2022, and it promises to be an eventful year. That’s right, it will be a gift that keeps on giving. I know almost two years into the COVID-19 pandemic, many of us have experienced fatigue, stress, fear, isolation, loss,…
Question of the Day – Monday January 31, 2022
In a patient with acetaminophen-induced hepatotoxicity, what may the thromboelastography (TEG) show? In a recent retrospective review of nine patients who were admitted for acetaminophen toxicity to a transplant center, TEG showed a decreased rate of fibrin formation and cross linking as well as decreased…
Question of the Day – Friday January 28, 2022
Immune Checkpoint Inhibitors result in a variety of adverse events. What is the newly emerging overlap syndrome that is associated with a high mortality? Myocarditis, myositis and myasthenia gravis. In a recent letter to the editor, Lipe DM et al. describe several reported cases of…
Question of the Day – Thursday January 27, 2022
What does this mathematical equation describe: [(All current cases at one point in time)/(Total Study Population)] Prevalence. DiSalvo P and Su MK. Biostatistics and Epidemiology for the Toxicologist: Incidence and Prevalence. JMT 2022; 18: 56-57.
Question of the Day – Wednesday January 26, 2022
When thinking about biostatistics and epidemiology, what does this definition describe? “The occurrence of new cases of disease or injury in a population over a specific period of time” Incidence. DiSalvo P and Su MK recently pubished a review discussing accurate epidemiologic terminology. Incidence and…
Question of the Day – Tuesday January 25, 2022
This drug resulted in higher levels of FEV1, FVC and FEV1/FVC in patients with pulmonary fibrosis caused by acute paraquat poisoning. Pirfenidone. Ren W et al. recently published results of 86 patients with pulmonary fibrosis caused by acute paraquat poisoning. The pirfenidone group had higher…
Question of the Day – Monday January 24, 2022
What is the very potent oxidant responsible for acetaminophen’s toxicity? Peroxynitrite. Protein adducts in mitochondria trigger superoxide formation which eventually leads to phosphorylation of c-jun N-terminal kinase (JNK) which triggers further impairment of the electron transport chain which leads to mitochondrial superoxide formation through complex…
Question of the Day – Friday January 21, 2022
Which halogenated hydrocarbon can lead to a reversable, subacute neurotoxicity and is now being marketed as a new form of “poppers”? Ethyl chloride has been reported to cause a reversable, subacute neurotoxicity that is imaging negative. Prior reports document ataxia, cerebellar dysfunction, drowsiness. Death has…
Question of the Day – Thursday January 20, 2022
What was the effect of the water supply change in Flint, MI on pediatric blood lead levels? A retrospective analysis analyzed blood lead levels (BLL) in Flint children aged 5 years and younger over three periods: Period 1 from 25 April 2006 to 15 October…
Question of the Day – Wednesday January 19, 2022
Exposure to low levels of this metal in drinking water has been correlated with increased rates of cerebrovascular disease, diabetes mellitus, and kidney disease? A standardized mortality ratio analysis was conducted in a contiguous six-county area of southeastern Michigan to investigate the relationship between moderate…