Administrator Clintox - One

Historical QOD 4/27/24: Nitrous oxide is capable of oxidizing the cobalt atom in the vitamin B12 molecule resulting in an irreversible inhibition of methionine synthase. This mechanism may result in the development of a myeloneuropathy in individuals exposed to nitrous oxide. What profession is most…

In children, seizures occurred in what percentage of diphenhydramine overdoses? According to the cited resource, between 2008-2015, in diphenhydramine only products, seizures occurred in 5.5% of cases. Palmer RB, Reynolds KM, Banner W, Bond GR, Kauffman RE, Paul IM, Green JL, Dart RC. Adverse events…

What two pregnancy/birth related complications were affected in a Swedish population of women working at a smelting factory? According to the cited resource, both an increased frequency of spontaneous abortion and low birth weight were found in females who had been employed during or around…

Following an acute toxic ingestion of salicylates in an adult patient, what factors suggest an unfavorable outcome? According to the cited reference, older age, elevated initial serum lactate levels, elevated respiratory rate Shively, R. M., Hoffman, R. S., & Manini, A. F. (2017). Acute salicylate…

A systematic literature review and meta-analysis was undertaken that included studies with participants aged ≥ 12 with non-cancer pain of ≥ 3 months duration, treated with opioid analgesics. What was the prevalence of dependence and opioid use disorder (D&OUD)? The pooled prevalence of D&OUD was…

Historical QOD 4/24/09: What cardiac glycosides are contained in the plant Digitalis purpurea (Foxglove)? Digitalis purpurea yields digitoxin and gitoxin from its leaves and digitalin in the seeds. It does not contain digoxin, which is present only in the leaves of its cousin Digitalis lanata….

A large dataset from Canada and America compared pregnant to non-pregnant individuals, and showed what difference in prevalence of CBD use between these groups? The prevalence of CBD use in pregnant individuals was 20.4% compared with 11.3% among nonpregnant people (P<.001). The most common easons…

What phytomenadione dose/dose frequency was required to gain adequate coagulation control in brodifacoum adulterated synthetic cannabinoids exposures in Israel? What was the goal for coagulation control? Phytomenadione 20 mg Q8h, aiming for an INR < 1.5 Lurie Y., Nadir Y., Hoffman R, et. al (2023)….

According to a recent publication, what is the proposed mechanism of why higher serum concentrations of fentanyl were found in overdose patients with xylazine as an adulterant compared to overdose patients without xylazine in the supply? Xylazine, an 𝛂-2 agonist, is hypothesized to release less…

How did patients with co-ingestion of gamma hydroxybutyrate compare with patients with co-ingestion of benzodiazepines in methamphetamine exposure cases described in a 2024 publication? Patients who presented with co-ingestions of gamma hydroxybutyrate had a significantly higher serum concentration of methamphetamine but lower presenting heart rate…