In a recent porcine model of carbon monoxide poisoning, the lactate to pyruvate ratio was elevated compared to the control group. What do the authors hypothesize this is due to?
The lactate/pyruvate ratio (LPR) is often an indication of dysfunction within the electron transport chain which they hypothesize supports the overall mitochondria dysfunction at the level of the brain. This occurred with low doses of CO used in their study.
Jang DH et al. Alterations in cerebral and cardiac mitochondrial function in a porcine model of acute carbon monoxide poisoning. Clin Tox 2020, Ahead of print, 1-14. https://doi.org/10.1080/15563650.2020.1870691
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