According to a recent systematic review of ethylene glycol poisoning, what was the glycol concentration that best predicted acute kidney injury?
AKI was expected if the glycolate concentration was >12.9 mmol/L, (sensitivity 78.5%, specificity 88.1%, positive predictive value 86.4%, negative predictive value 80.9%). This correlated to an anion gap >28 mmol/L. The glycolate concentration threshold for a 95% negative predictive value for acute kidney injury was 6.6 mmol/L.
Roberts DM, Hoffman RS, Brent J, et al. The serum glycolate concentration: its prognostic value and its correlation to surrogate markers in ethylene glycol exposures. 2021.